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My research program has 3 main pillars in order to span the spectrum of mechanistic human physiology studies to community-based participatory action research. Pillar 1: the determinants of type 2 diabetes and the associated complications, Pillar 2: dose of physical activity needed to prevent type 2 diabetes and improve metabolic control in individuals with type 1 diabetes, Pillar 3: the role of peer mentoring for the prevention and treatment of type 2 diabetes in youth. 

Publications

Associate Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Co-Lead of the DREAM Theme and the Developmental Origins of Health and Disease in Youth Research Cluster (DEVOTION)
CIHR Applied Public Health Chair in Resilience and Childhood Obesity
Research Scientist, Children’s Hospital Research Institute of Manitoba
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Dr. Halayko’s research program is deciphering biological processes in debilitating and burdensome chronic lung diseases like asthma. He addresses why no current drugs fully control or reverses asthma in all patients, focusing on mechanisms that lead to diversity in disease severity and response to therapies. He uses unique resources of human lung cells and tissues, small animal models, lipidomics, proteomics and metabolomics to monitor the response to environmental factors. His work is uncovering unique pathobiology mechanisms linked to oxidative stress in the lungs. Through research networks his work is positioned for rapid translation into new therapeutics that meet unmet clinical need, resulting in first-in-human trials. In his career Halayko has 222 publications in recognized international journals. Halayko is holds national leadership roles, as an executive member of the CIHR-Canadian Respiratory Research Network, an original member of research steering committees for both the Manitoba- and Canadian-Lung Association, and is currently President of the Canadian Thoracic Society.

Publications

Professor, Department of Physiology and Pathophysiology, and Internal Medicine, Max Rady College of Medicine
Canada Research Chair in Airway Cell and Molecular Biology
Lead, Biology of Breathing Group
Research Scientist, Children’s Hospital Research Institute of Manitoba

Andrew Halayko  PhD, FCAHS

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Professor Abdelilah Soussi Gounni received his Ph.D. from Pasteur Institute, University of Lille, France under the mentorship of Dr. M. Capron, and then underwent training as a National Swiss Foundation Research fellow at the Swiss Tropical Institute University of Basel,  and  as a postdoctoral fellow at the Meakins Christie Labs under the mentorship of Dr. Qutayba Hamid.

 In 1999, Dr.Gounni was one of only 6 investigators worldwide recognized with a Pharmacia Allergy Research Foundation fellowship award for his innovative research on IgE receptor mediated inflammation.

In 2001, Dr. Gounni joined the Department of Immunology at the University Of Manitoba Faculty Of Medicine where he established a competitive program investigating the   molecular mechanism of airway chronic inflammation.

Publications

Professor, Department of Immunology, College of Medicine, University of Manitoba

Abdelilah Soussi Gounni, PhD

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The overreaching aim of the West laboratory is to improve our understanding of how mechanobiology principles and structural/mechanical changes contribute the pathogenesis of lung disease. This aim presently incorporates three specific research direction:

Ongoing development of cutting-edge tools to manipulate the cellular mechanical environment and measure innovative endpoints. This includes polyacrylamide hydrogels, 3D tissue-engineered smooth muscle, epithelial Transwell culture systems, and ex vivo lung tissue.

Understanding the basal regulation of lung cellular function by mechanobiology, particularly relating to the contractile function of airway and pulmonary vascular smooth muscles and the barrier function of airway epithelium.

Examining synergistic interactions between mechanobiology and traditional signalling pathways. This includes but is not limited to TGF-beta and RhoA signalling pathways, and how/where these pathways interact at focal adhesions, caveolae and the cytoskeleton.

Publications

Assistant Professor, Department of Physiology, Max Rady College of Medicine
Research Scientist, Children’s Hospital Research Institute of Manitoba

Adrian West, PhD

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Dr. Becker’s primary research interest is the interrelationship of allergy, asthma and the environment.  He is co-principle investigator of “A Multi-Centre Study on the Efficacy of an Intervention Program to Prevent the Development of Asthma in High-Risk Infants”.  Dr. Becker is also very involved with Asthma Education and has contributed to development of a Prairie Asthma Educator Education program.  He is principle investigator for evaluation of the Children’s Asthma Education Project in Manitoba.

Publications 

Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Section Head, Allergy and Clinical Immunology
Manitoba Co-Lead, Canadian Healthy Infant Longitudinal Development (CHILD) Study
Clinical Research Scientist, Children’s Hospital Research Institute of Manitoba

Allan Becker, MD, FRCPC

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My research interests are in the epidemiology of chronic disease (CKD) in Indigenous children, with a current focus on renal outcomes in youth with type 2 diabetes. Currently the co-lead of the National iCARE study, funded by CIHR which will evaluate the bio-psychosocial determinants of albuminuria in youth with type 2 diabetes. 

Publications 

Assistant Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine, Section of Pediatric Nephrology
Clinical Research Scientist, Children's Hospital Research Institute of Manitoba

Allison Dart, MD, MSc, FRCPC

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Research Focus
1). Long-term Cardio-Respiratory outcomes of extremely preterm infants.

2). Mechanistic studies of bronchopulmonary dysplasia (BPD) in newborn rats.

3). Development of new therapies (Mesenchymal stromal cells from preterm infant umbilical cord) in preclinical and future clinical BPD.

Publications 

Principle investigator-Biology of Breathing Theme, Children’s Hospital Research Institute of Manitoba; Assistant Professor-Staff Neonatologist, Department of Pediatric, The University of Manitoba.

Ann Yi, MD, PhD

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Obesity is a growing problem in Canada, and has reached pandemic proportions. According to the World Health Organization, nearly two billion people worldwide were overweight and/or obese in 2016. Recent epidemiological studies have established a link between obesity and cancer, with obese people being predisposed to cancer, though the underlying mechanisms are unclear. The primary focus of my research program is to decipher the intracellular and extracellular signaling that regulates the interplay between tumor metabolism and host physiology. More specifically I am interested in elucidating the biochemical and physiological changes in skeletal muscle and adipose tissue as a result of crosstalk between host metabolic tissues and tumor itself via extracellular vesicles. My research will be done in the context of chronic diseases (obesity and type 2 diabetes) and modifiable lifestyle interventions such as exercise. The long-term goals of my research program are to understand: (A) the pathophysiology of tumorigenesis on host metabolism and (B) therapeutic benefits of exercise in hopes of creating a knowledge base that can turn into mainstream healthcare practice. My research program will be instrumental in promoting optimal health and well being of individuals, families, communities, and diverse populations, nationally and globally.

Publications

Assistant Professor, Faculty of Kinesiology and Recreation Management

Ayesha Saleem, PhD

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Dr. Chauhan’s research program is focused on asthma, which has three distinct pillars covering from evidence synthesis to clinical and basic research.

Pillar I: Dr. Chauhan, in affiliation with Knowledge Synthesis Platform, George and Fay Yee Centre for Healthcare Innovation and Cochrane Airways Group, UK, conducts knowledge synthesis projects including systematic reviews, meta-analysis, and rapid reviews. Dr. Chauhan published 9 Cochrane Systematic reviews, which are cited in the Canadian Asthma Guideline 2012 update & Global Initiative for Asthma (GINA) 2014.

Pillar II: Dr. Chauhan is involved in clinical research in children and adults with asthma. Dr. Chauhan earned 12 years of affluent clinical research experience including bioequivalence and bioavailability studies in healthy human volunteers.

Pillar III: Dr. Chauhan is exploring mechanisms, role of determinants in inception and intensification of asthma exacerbation, and new therapeutic targets using laboratory animals and state of the art technology.

Publications

Assistant Professor, Faculty of Pharmacy, University of Manitoba
Research Associate and Review Manager, George and Fay Yee Centre for Healthcare Innovation
Member, Biology of Breath Theme
Research Associate, Department of Pediatrics, University of Montreal

Bhupendrasinh Chauhan, PhD

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My research focus is on child and adolescent type 2 diabetes, including the socioeconomic, environmental, in utero, and endogenous determinants of childhood diabetes onset. Current research is evaluating the fetal orgins of childhood onset type 2 diabetes, including in utero and epigenetic modifications. 

Publications 

Assistant Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Pediatric Endocrinologist at HSC
Clinical Research Scientist, Children’s Hospital Research Institute of Manitoba

Brandy Wicklow, MD

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Dr. Rodd’s research focuses on calcium homeostasis and bone physiology and their associated disorders. She is particularly interested in defining optimal vitamin D intake for healthy Canadian children. Her work assessing vitamin D adequacy in the paediatric population includes novel functional outcomes, such as muscle strength, balance and body composition. These studies determined that 400IU/day of vitamin D is sufficient for normal bone mineralization and accrual in healthy children.

Publications

Assistant Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Clinical Research Scientist, Children’s Hospital Research Institute of Manitoba

Celia Rodd, MD, MSc, FRCPC

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Dr. Charles Wong is an expert on measuring organic contaminants in the environment, and understanding their behavior and effects on non-target organisms and their ecosystems. He received his SB and SM degrees from the Massachusetts Institute of Technology (MIT), and his PhD from the University of Minnesota, all in civil and environmental engineering. He also received postdoctoral training from the US Environmental Protection Agency and Environment Canada. Wong holds concurrent academic appointments at the University of Manitoba, the Children's Hospital Research Institute of Manitoba, and the Costa Rica Institute of Technology. He is also an Associate Editor of Environmental Pollution, an international scientific journal in the top 10% in the field of environmental sciences.

Wong has won several international awards for his research, including the Society of Environmental Toxicology and Chemistry's Weston Solutions Environmental Chemistry Award for the top environmental chemist of the year under age 40. Since joining The University of Winnipeg in 2008, he has helped to secure over $12 million in external research funding as of September 2016. His undergraduate, graduate, and postdoctoral students have to date collectively won 18 fellowships and 23 best-research-presentation awards at all local and international levels.

Publications

Professor and Canada Research Chair in Ecotoxicology

Charles Wong, PhD

I joined the Children’s Hospital Research Institute of Manitoba when I came on faculty in 2009 to increase my exposure to the research being done in Child Health.

My primary research focus is outcomes of neonates in Manitoba using the Data Repository at the Manitoba Centre for Health Policy.

My current interest is adding to the growing body of research looking at outcomes of diabetes in Manitoba, particularly maternal diabetes and infant and child outcomes.

Publications

Assistant Professor in Paediatrics and Child Health Section of Neonatology, University of Manitoba
Researcher, Manitoba Centre For Health Policy

Chelsea Ruth, MD, FRCPC

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My research program aims to identify novel metabolic and molecular mechanisms that control the dynamic daily cycles of insulin secretion from the pancreatic beta cell, and to determine how exposure to various risk factors associated with type 2 diabetes impacts these daily cycles of insulin secretion. 

Publications 

Assistant Professor, Department of Physiology & Pathophysiology, Max Rady College of MedicineResearch Scientist, Children's Hospital Research Institute of Manitoba

Christine Doucette, PhD

My research focus is the primary and secondary prevention of childhood allergic diseases, including food allergy, asthma and atopic dermatitis. My research team is evaluating the development of food allergy, in particular peanut allergy, among a population-based group of children participating in the CHILD cohort study. I am also working with the Asthma and Anaphylaxis Educators of the Childhood Allergy and Asthma Education Centre (CAAEC) to evaluate anaphylaxis management in schools and high-risk asthma outcomes.

Publications

Assistant Professor, Section of Allergy, Department of Pediatrics & Child Health, University of Manitoba;
Clinician Scientist, Children’s Hospital Research Institute of Manitoba;
Associate Investigator, Canadian Healthy Infant Longitudinal Development (CHILD) National Cohort Study

Elinor Simons, MD, PhD, MSc, FAAAAI, FAAP

Elizabeth's main areas of research focus are on pediatrics, endocrinology and metabolism, epidemiology, type 1 diabetes, type 2 diabetes, obesity, and metabolic syndrome.

Publications

Associate Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Clinical Research Scientist, Children's Hospital Research Institute of Manitoba

Elizabeth Sellers, MD, MSc, FRCPC

I come with a diverse background starting my career as a Family First home visitor after receiving my Child and Youth Care Diploma from Red River College. This was a very eye opening position and I learned a lot working in Public Health. After 6 years, I received a wonderful opportunity to start my career in research, as a research assistant at the Children’s Hospital Research Institute of Manitoba with a pediatric endocrinologist who focused his research in Type 1 Diabetes. I have since worked in several different research administrative positions at CHRIM. As Project Coordinator with DEVOTION, it is very interesting to see how my original roots with Family First are resurfacing with some projects.

DEVOTION Program Coordinator

Erika Bloomfield

Dr. Shen’s research has three primary areas of focus: the mechanism and treatment for diabetic vascular complications; the impact of gestational diabetes on mothers and offspring; and the effect of physical activity and nutritional education on pregnancy outcomes.

Publications

Professor, Department of Internal Medicine, Max Rady College of Medicine
Associate Director, Diabetes Research Group
Clinical Research Scientist, Children's Hospital Research Institute of Manitoba

Garry Shen, MD, PhD

I do a combination of clinical work as a pediatrician and clinical research in pediatrics, specifically in children with obesity and/or diabetes, looking at the effects of these diseases and genetics on medication use, and the use of innovative therapies for the prevention and treatment of these conditions and diseases.  

Publications 

Assistant Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Clinical Research Scientist, Children's Hospital Research Institute of Manitoba

Geert t'Jong, MD, PhD

Dr. Hatch's three main areas of research are  1) Biology of Cariolipin (CL): examining regulation of the metabolism CL, 2) Biology of Human Lipid Disorder: investigating the role of TAZ in CL metabolism and Barth Syndrome, 3) Biology of the Blood Brain Barrier: examining mechanisms that govern transport across human brain microvessel endothelial cells and the role that CL plays.

Publications

Professor, Department of Pharmacology, Biochemistry and Medical Genetics, Max Rady College of Medicine
Director of the Lipid Lipoprotein and Atherosclerosis Research Group (LLARG)
Director of the Centre for Research and Treatment of Atherosclerosis

Grant Hatch, PhD

My current research is exploring the mechanisms by which histone modifications associated with the transcribed genes body communicate with proteins associated with RNA to regulate pre-mRNA splicing. Most recent research endeavors are exploring the role of DNA methylation in diseases such as fetal alcohol spectrum disorder and type 2 diabetes.  

Publications

Professor, Department of Biochemistry and Medical Genetics, Max Rady College of Medicine
Director, Manitoba Epigenetic Network
Canada Research Chair, Chromatin Dynamics
Research Scientist, Children's Hospital Research Institute of Manitoba

James Davie,  PhD

Jan graduated with her Masters degree in Public Affairs in 1980. The first ten years of her career were spent in Saskatchewan working for first for the Federal government and subsequently for the Province. In 1989 she returned to her roots in Manitoba and began a 27 year career with the Province of Manitoba, spanning a range of progressive assignments in human resources, labour relations, and program management. In 2001, Jan became the CEO of Healthy Child Manitoba, reporting to the Healthy Child Committee of Cabinet.  In 2009, this role was merged with her new assignment as Deputy Minister of Healthy Living, Youth and Seniors. In 2012, while retaining her CEO role, Jan was appointed Deputy Minister of the newly created Department of Children and Youth Opportunities. In 2016, Jan left the Province of Manitoba and became a Research Chair at Red River College

Publications

Research Chair at Red River College

Jan Sanderson, MA

Jeff LaPlante is Métis (Saulteaux and French) from the Red River Valley, Red Lake Minnesota, Woodridge, Manitoba, and Winnipeg. Jeff has worked in the fields of human rights, First Nations self-government, First Nations community-based research and advocacy, program development and delivery, and Indigenous health and wellness since graduating from the University of Manitoba in 2001. Jeff envisions an expanded reach and network for NADA, based on existing connections and relationships, and looking to extensive partnerships and collaborations with diabetes-related health researchers; programs and services; and community-based practitioners, knowledge-keepers and healers.

Executive Director, National Aboriginal Diabetes Association

Jeff LaPlante

I am currently working as part of the Study of Allergy, Genes and the Environment.  This multidisciplinary study is focused on the 1995 Manitoba Birth Cohort to investigate clinical, genetic, immunologic, endocrinologic and sociologic factors believed to be involved in the development of asthma and obesity in adolescent girls.

The objective of my study is to examine the effects of cultural and social environmental factors, and agents of socialization on behaviours associated with obesity in asthma.  Over the past 2 decades, both childhood obesity and diagnosis of asthma in children have increased.  My study will examine a possible relationship between the two.  Questionnaires designed to provide information on the interactive effects of several factors on health status, including social and environmental factors, which include gender, socio-economic status, parental education, and ethnicity, are being administered to participating children. As well, risk behaviours, such as eating, intensity of dieting efforts, and level of physical activity, will be considered. These findings will then be correlated with the children’s anthropometrical measurements and lung function tests. 

Publications

Human Nutritional Sciences

Jennifer Protudjer, M.Sc 

Dr. Gordon’s research focuses on the regulation of mitochondrial function during cardiac and skeletal muscle differentiation and remodeling, including hypoxia/ischemia, diabetic cardiomyopathy, and insulin resistance.Dr. Gordon’s laboratory utilizes cell and molecular approaches to understand mitochondrial function, dynamics, and turn-over including the regulation of mitophagy and mitochondrial permeability transition. Specifically, Dr. Gordon’s laboratory studies the transcriptional regulation and post-translational modification of Bcl-2 family members utilizing both primary and immortalized cells, differentiated human induced pluripotent stem cells, and conditional knockout mice.

Publications 

Associate Professor, College of Nursing
Research Scientist, Children's Hospital Research Institute of Manitoba

Joe Gordon, PhD

Research Focus

Bacterial cell-cell signalling and interactions

Microbiome and biofilms

Bacterial pathogenesis and antibiotic resistance

Development of new antimicrobials

Publications

Associate Professor, Department of Oral Biology and Department of Medical Microbiology, Faculty of Health Sciences, University of Manitoba

Kangmin Duan, PhD

Kozeta holds a Medical Doctorate from the Medical University of Tirana in Albania, and a PhD from Erasmus University in the Netherlands, where she also obtained her MSc and DSc in Clinical Epidemiology. Kozeta’s postdoctoral studies are focused on the impact of maternal factors on human milk oligosaccharides and subsequently on obesity and cardiovascular health in children.

Publications

Postdoctoral Fellow

Kozeta Miliku, MD, PhD

My career started as a physiotherapist with a specific interest in using physical activity as a tool to prevent and manage obesity-related conditions in youth. My current research merges the areas of knowledge translation with pediatric obesity and rehabilitation. One of my main studies underway is a provincial and national mapping system of available pediatric weight management services.

Publications 

Assistant Professor, Departemnt of Pediatrics and Child Health, Max Rady College of Medicine
Director of Knowledge Translation, George and Fay Yee Centre for Healthcare Innovation
Research Scientist, Children's Hospital Research Institute of Manitoba

Kristy Wittmeier, PT, MSc, PhD

forthcoming

Director, Policy Development, Research and Evaluation at Health Child Manitoba Office

Leanne Boyd

Leona comes to us with a vast background in Indigenous participatory action research, cultural approaches to health, education, and leadership experience. Leona is a Cree woman from Thunderchild First Nation, Saskatchewan, within the Treaty 6 Territory in Canada.  She studied at the First Nations University of Canada, before moving to Manitoba, where she worked for the Assembly of Manitoba Chiefs and now the First Nations Health and Social Secretariat of Manitoba (new health entity established by Chiefs in Assembly).

 

She currently works as a Research Associate on multiple projects within Nanaandawe'iyewigamig and is the Manitoba lead Regional Coordinator of two national surveys; the Regional Health Survey (RHS) and Regional Early Childhood, Education and Employment Survey (REES). She is a strong advocate of First Nations self-determination in research grounded in the First Nations principles of Ownership, Control, Access and Possession (OCAP). Leona will be working for the most part from Nanaandawewigamig (First Nations Health and Social Secretariat of Manitoba).

Publications

DEVOTION Indigenous Program Director

Leona Star 

Dr. Roos is an Assistant Professor in the Department of Psychology at the University of Manitoba in Winnipeg, Canada. Her appointment is across Child Clinical Psychology and School Psychology specialties. She will be accepting graduate students in the Fall 2019 school year and students are encouraged to email her directly with a description of their interests in working with her and research background.

Dr. Roos recently completed her APPIC accredited psychology residency at the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada and received her PhD from the University of Oregon as a member of the Stress, Neurobiology and Prevention Lab and Centre for Translational Neuroscience. Dr. Roos consults with the Frontiers of Innovation group at the Harvard Centre on the Developing Child on program design and intervention evaluation. She is also the chair of the Academic Research Committee at the Until the Last Child charitable foundation.

Publications

Clinical Psychology Resident, Centre for Addiction and Mental Health, 2018
PhD, Clinical Psychology, University of Oregon, 2018
MS, Clinical Psychology, University of Oregon, 2012
BS, Psychology; BA, Visual Arts, Brown University, 2010

Leslie Roos, AB, PhD

Research Focus: Biomaterials, Nanomedicine and Stem Cells for Tissue Regeneration (Bone, Cartilage, Airway, Vascular Graft and Skin)

Publications

Assistant Professor Nano-Medicine and Tissue Engineering Lab Department of Mechanical and Manufacturing Engineering, Faculty of Engineering Department of Biochemistry and Medical Genetics, Faculty of Medicine University of Manitoba

Malcolm (Mengqiu) Xing, PhD

Dr. Meaghan Jones received her BScH in Biology from Mount Allison University, and her PhD in Medical Genetics from the University of British Columbia. She pursued post-doctoral training at the University of British Columbia studying epigenetics of early life environments with Dr. Michael Kobor, before joining the Department of Biochemistry and Medical Genetics at the University of Manitoba in 2018. Dr. Jones’ current focus is the role of epigenetic changes in the link between mothers’ exposure to inhaled pollutants like cigarette smoke and their children’s risk of developing asthma. Students and staff in her lab have the opportunity to use large epigenetic data sets from human birth cohort studies to discover epigenetic changes associated with specific environmental exposures. These findings inform further experiments using model systems to understand the molecular and developmental impacts of prenatal exposures, leading to a truly multi-disciplinary learning experience.

Publications

Assistant Professor, Department of Biochemistry and Medical Genetics
Member, UM Centre on Aging

Meaghan Jones, PhD

My research focuses on the developmental orgins of health and disease, and aims to clarify the influence of breasfeeding on infant health and development, identify the bioactive components of human milk that underlie these associations, and determine how maternal characteristics influence breastfeeding, milk composition and infant health. 

Publications 

Assistant Professor, Department of Pediatrics and Child Health, Max Rady College of Medicine
Manitoba Co-Lead - Canadian Healthy Infant Longitudinal Development (CHILD) Study
Co-Lead - Population Health, DEVOTION
Research Scientist, Children's Hospital Research Institute of Manitoba

Meghan Azad, PhD

My journey and passion in patient care, research and advocacy, began in the Department of Surgery in the clinical scope of Pediatric Orthopedic Surgery and evolved to include a focus in postgraduate/undergraduate surgical education in the specialty of Neurosurgery.  I had the opportunity to expand the surgery education network beyond the University of Manitoba through the design and implementation of new and innovative cross-institutional curriculum blocks and academic sessions.  As appointed Chair for staff development for the new Royal College competency-based medical education model, I spearheaded initiatives to help change the framework of medical education; inspiring individuals to become invested in their medical education programs and teams.

My role in the DEVOTION Network furthers my journey, allowing me to contribute to the changing landscape of patient care by providing opportunities to lead and facilitate projects that support the vision of the DEVOTION team.

DEVOTION Executive Director

Natalie Rodriguez

Dr. Nickel is an active member of the International Society for Research in Human Milk and Lactation. He has served the American Public Health Association in a variety of capacities; currently, Dr. Nickel is Scientific Chair of Breastfeeding and sits on the conference planning committee for the Annual Meeting of the American Public Health Association.


As a Research Scientist at the Manitoba Centre for Health Policy, Dr. Nickel serves as either principal investigator, co-principal investigator, or co-investigator on government funded studies on issues impacting the health of Manitobans and/or delivery of healthcare services in Manitoba.

Publications 

Assistant Professor,  Manitoba Centre for Health Policy, Max Rady College of Medicine

Nathan Nickel, PhD

Dr. Mookerjee’s research interest is in the understanding of mechanisms underlying the regulation of chronic inflammation. Her laboratory studies small molecules, with particular focus on cationic host defense peptides (HDPs), to define protein changes and signaling networks that underlie the role of HDPs in regulating chronic inflammation. Research projects in her lab examines the effects of HDPs and their synthetic mimics known as innate defense regulator (IDR) peptides in two disease models; inflammatory arthritis and allergic asthma. This research adds a new dimension for the use of IDR peptides as immunomodulatory therapy to control inflammation without compromising resistance to infections.

Publications 

Associate Professor, Department of Internal Medicine & Immunology, Max Rady College of Medicine

Neeloffer Mookherjee, PhD

Patricia Gregory RN, PhD, is the Coordinator for Research and Scholarship in the Bachelor of Nursing Program at Red River College and holds an Assistant Professor Appointment in the College of Nursing, Rady Faculty of Health Sciences at the University of Manitoba in Winnipeg, Manitoba. Dr. Gregory is a professional affiliate with the Manitoba Centre for Nursing and Health Research. Her research has been on health services with a focus on prenatal care. 

Publications

Assistant Professor, College of Nursing

Patricia Gregory, RN, PhD

Dr. Fernyhough was born and educated in East London, UK, and performed his B.Sc. degree in Biological Sciences at the University of Essex. Dr. Fernyhough performed his PhD in biochemistry in the department of Biochemistry (department of Sir Hans Krebs) at University of Sheffield in the UK. He also performed postdoctoral research at Colorado State University, Kings College London (department of Maurice Wilkins) and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College (department of Sir John Vane). Drs Krebs, Wilkins and Vane are all Nobel Prize winners. All of these positions spanned 1985-1998. Dr. Fernyhough subsequently worked for 5½ years (1998-2004) as a fully tenured lecturer in the School of Biological Sciences (now the Faculty of Life Sciences) at the University of Manchester. Dr. Fernyhough’s general research interest is in the cell biology underlying neurodegenerative disorders of the peripheral and central nervous systems

Dr. Fernyhough is studying the etiology of the peripheral nerve damage observed in patients with diabetes. In addition he is researching the link between Alzheimer’s disease and Type 2 diabetes. “In patients with Alzheimer’s disease there is an increased risk of developing diabetes and these patients exhibit more severe and accelerated memory loss” says Dr. Fernyhough. Our studies are focused on identifying key signaling pathways that are impaired in animal models of Alzheimer’s disease. A major direction of the lab is to determine whether improper insulin signal transduction in neurons is central to axon and neuronal loss.

Publications

Director, Division of Neurodegenerative Disorders
Principal Investigator, Cell Biology of Neurodegeneration Lab, Division of Neurodegenerative Disorders
Professor, Pharmacology & Therapeutics, University of Manitoba
Department Head, Pharmacology and Therapeutics, Max Rady College of Medicine
Rady Faculty of Health Sciences, University of Manitoba

Paul Fernyhough, PhD, BSc

Research Focus:

G protein-coupled receptors (GPCRs) constitute the largest known family of cell surface receptors. These receptors transduce signals across the cell membranes in response to diverse extracellular stimuli. GPCRs are involved in fundamental biological processes such as sensing taste, light, odor, and in various other physiological functions. Typically 40% of the prescription pharmaceutical drugs target these GPCRs. The Chelikani laboratory uses genetic, biochemical and biophysical techniques to study the signaling mechanisms of these receptors. The current research focus is on few GPCRs, the human bitter taste receptors and the prostanoid receptors.

Publications

Professor, Department of Oral Biology, University of Manitoba
Scientist, CHRIM
Director, Manitoba Chemosensory Biology (MCSB) Research Group

Prashen Chelikani, PhD

Rachel has experience in the education, social services and Indigenous health services. She studied at the University of Winnipeg. Her position within DEVOTION is focused on knowledge translation, public/patient engagement and bridging the gap between researchers and community. When she’s not in her Patient Engagement Coordinator role, she’s the Program Manager for the Clinical Research Unit, another part of CHRIM.

DEVOTION Patient Engagement Coordinator

Rachel Keijzer, BEd, MA

Dr. Randall Fransoo is a Senior Research Scientist and the Associate Director of Research at the Manitoba Centre for Health Policy (MCHP), and an Assistant Professor in the Department of Community Health Sciences at the University of Manitoba. He has led MCHP projects on a variety of topics, including several Atlas-style population health reports (one on Sex Differences), and recent studies on the use of hospital beds and ICUs in Manitoba, plus a report on Adult Obesity. Randy is also the Director of The Need To Know team, a national award-winning research collaborative involving high level representatives from all Health Authorities in Manitoba, along with provincial policy makers. His research interests include clinical epidemiology projects with colleagues in Critical Care, Cardiac Sciences, and Anesthesia. He recently co-founded the Manitoba Acute Coronary Syndromes Network, and leads its Research Committee.

Publications

Assistant Professor, Community Health Sciences, Max Rady College of Medicine
Senior Research Scientist and Associate Director of Research, Manitoba Centre for Health Policy 

Randy Fransoo, MD

Dr. Keijzer’s clinical interest concentrates on minimal invasive Pediatric General Surgery and his research focuses on congenital anomalies in general and congenital diaphragmatic hernia and pulmonary hypoplasia in particular.  Currently, his laboratory focuses on the role of two microRNAs: miR-10a and miR-200b during normal and abnormal lung development due to CDH. In the near future he wants to explore methods for prenatal therapeutic intervention to modulate the natural course of pulmonary hypoplasia and CDH to improve the outcome of babies born with this anomaly.

Publications 

Associate Professor, Departments of Surgery, Pediatrics & Child Health and Physiology, Max Rady College of Medicine
Clinical Research Scientist, Children's Hospital Research Institute of Manitoba

Richard Keijzer, MD, MSc, PhD

Dr. Schroth’s main research interests include Early Childhood Caries (ECC) and the role that nutrition and prenatal factors have on infant and preschool oral health. Two major studies are investigating the relationship between vitamin D deficiencies and both enamel hypoplasia and ECC in an urban Aboriginal population. He has also been involved in other ECC epidemiological work involving Aboriginal, rural, and Hutterite preschool populations. Dr. Schroth is a key participant in the Healthy Smile Happy Child Project (The Manitoba Collaborative Project for the Prevention of Early Childhood Tooth Decay), a Manitoba Health grant funded project guided by the pillars of community-development, oral health promotion/education, and research/evaluation. This project has partnered with communities to produce needed oral health promotion resources and has undertaken both quantitative and qualitative studies relating to preschool oral health in Manitoba. He also has an interest in health policy and Aboriginal health. In addition to his research program he practices part-time at two community clinics where he cares for many young children with ECC.

Publications

Associate Professor, (cross-appointed), Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba;
Associate Professor with Tenure, Department of Preventive Dental Science, College of Dentistry, University of Manitoba;
Associate Professor, Department of Pediatrics & Child Health, Max Rady College of Medicine, University of Manitoba;
Associate Professor (cross-appointment), Department of Oral Biology, College of Dentistry, University of Manitoba

Robert Schroth, DMD, MSc, PhD

Dr. Alvaro is a neonatologist and Associate Professor of Pediatrics & Child Health at the University of Manitoba with professional activities that include education, research, and clinical care. His research focuses on control of breathing in the fetus and in newborns and he investigates the phenomenon of apnea of prematurity in which prematurely born infants sometimes stop breathing. His work has impact at the bedside as he shows that exposure to elevated levels of CO2 for short durations can prevent breathing interruptions until babies are more fully developed.

Publications

Acting Head Neonatology, Associate Professor, Pediatrics

Ruben Alvaro, MD

In past 10 years, my research has been focused on developing new therapeutic approaches in lung cancer, cardiopulmonary diseases, and infection disease based on modification of apoptosis, autophagy, and unfolded protein response (UPR) pathway. My long-term research plan will be built based on the following major topics:

Role of Autophagy and UPR in Regulation of Transforming Growth Factor beta 1 (TGF-b1)-induced Epithelial Mesenchymal Transition (EMT) in Lung Cancer Model
Targeting Mevalonate Cascade as New Approach for Breast Cancer Therapeutic Strategies
Modulation of Influenza Virus Replication by Targeting Apoptosis/Autophagy/UPR

Publications

Researcher, Children’s Hospital Research Institute of Manitoba;
Assistant Professor, Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba;
Honorary Professor, Health Policy Research Centre, Shiraz Medical University, Shiraz, Iran.

Saeid Ghavami, PhD

RESEARCH FOCUS: Diabetes in pregnancy

CURRENT PROJECTS:

Diabetes in pregnancy: Knowledge Translation - research to improve outcomes (PART 1: Survey of experts) (Principal Investigator)

Diabetes in pregnancy: Knowledge Translation - research to improve outcomes (PART 2: Survey of patients) (Principal Investigator)

Effect of folic acid supplementation in pregnancy on preeclampsia (FACT - Folic Acid Clinical Study) (Site Investigator)

Bone Health in Women who had teen pregnancies (Supervising Investigator)

Teenage pregnancy: Effect on bone health for mother and child (Principal Investigator)

Publications

Director, Clinician Investigator Program, Faculty of Medicine
Associate Professor, Departments of Pediatrics and Child Health; Community Health Sciences; Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba
Scientist, Manitoba Institute of Child Health
Adjunct Scientist, Children's Hospital of Eastern Ontario Research Institute

Shayne Taback, MD, FRCPC

Dr. Dakshinamurti is a neonatologist and biomedical researcher at Children’s Hospital Research Institute of Manitoba, and Associate Professor of Pediatrics and Physiology at the University of Manitoba.  She is a member of the Biology of Breathing research theme, and the DEVOTION research cluster, dedicated to the developmental origins of cardiopulmonary disease. Dr.Dakshinamurti is Coordinator of Research within the Section of Neonatology, organizes the annual international Dr. JM Bowman Symposium on Neonatal Research, and functions as Research Director and Scholarly Oversight Committee Chair for the University of Manitoba’s Neonatal/Perinatal Medicine Fellowship Program. Her areas of research interest are pulmonary hemodynamics during circulatory transition, and the physiology and pharmacology of vascular smooth muscle in the neonatal pulmonary circuit.

Publications

Associate Professor, Department of Pediatrics & Child Health, Max Rady College of MedicineClinical Research Scientist, Children's Hospital Research Institute of Manitoba

Shyamala Dakshinamurti, MD, MSc, FRCPC, FAAP

forthcoming

PHC Study Coordinator/Community Development Specialist, iPHIT, FNSSM

Stephanie Sinclair

Dr. Alabdoulsalam completed his Bachelor of Medical Basic Science, and Bachelor of Medicine and Surgery at Kuwait University. Afterwards, he completed his general pediatric residency training at the University of Calgary. He also completed fellowship training in pediatric respiratory medicine at McGill University, and in sleep medicine at the University of Alberta.

2005 Pediatrics, American Board of Pediatrics

2008 Pediatrics, Royal College of Physicians & Surgeons of Canada

2008 Pediatric Respirology, Royal College of Physicians & Surgeons of Canada

2010 Pediatric Pulmonology, American Board of Pediatrics

2011 Sleep Medicine, American Board of Pediatrics

Research Focus: Pediatric respiratory and sleep-related breathing disorders

Publications

Assistant Professor, Section of Respirology, Department of Pediatrics & Child Health, Max Rady College of Medicine, University of Manitoba;
Director, Pediatric Respirology Fellowship Program, Department of Pediatrics & Child Health, Max Rady College of Medicine, University of Manitoba;
Director, Childhood Sleep Disorders Program, Health Science Center, Winnipeg, Manitoba

Tareq Alabdoulsalam, MBBCh, FRCPC, FAAP, FCCP, DABP(Sleep)

Research interests:

Physical activity and health research is an area of fundamental importance. Therefore, my research program focuses onto two major research themes: Basic exercise physiology and clinical exercise physiology.

Publications

Professor, Associate Dean (Research & Graduate Studies) Director, Health, Leisure and Human Performance Research Institute (HLHPRI)

Todd Duhamel, PhD

My research is focused on investigating the mechanisms involved in the development of gestational diabetes and how gestational diabetes contributes to the development of obesity, diabetes and related cardiovascular disease in youth. Our aim is to guide the development of novel therapies for obesity, diabetes and heart disease. 

Publications 

Associate Professor, Department of Pharmacology and Therapeutics, Max Rady College of Medicine
Dr. J. Moorehouse Fellow of the Diabetes Foundation of Manitoba
Research Scientist, Children's Hospital Research Institute of Manitoba
Co-Lead of the Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme
Research Scientist, Children’s Hospital Research Institute of Manitoba

Vern Dolinsky, PhD

forthcoming

Primary Health Care Nurse Manager, Innovation Supporting Transformation in Community-based Primary Healthcare Research Project (iPHIT), FNHSSM

Wanda Phillips-Beck

forthcoming

PEKE Coordinator - Partners for Engagement and Knowledge Exchange (PEKE), FNHSSM

Wendy McNab

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