Publications

Check out an article about the CHILD Study.

" Ilsa Buchholz doesn't remember much about all the tests and procedures she underwent during her last visit to the clinic at the Children's Hospital Research Institute of Manitoba.

After all, the nine-year-old was only five at the time, so her memory is a little hazy...."

Click here to read the rest of the paper.

CHILD researchers identify features and determinants of human milk microbiota composition which have potential implications for infant health and development.

Click here to read the paper.

Meghan Azad calls breastmilk "the ultimate personalized medicine" in a UM Today article.

Check out UM Today's article to learn why. 

 

Meghan Azad is a Tier 2 Canada Research Chair in the Developmental Origins of Chronic Disease (DOHaD) and DEVOTION's population pillar co-lead. Meghan's work within the DEVOTION Network, the CHILD study, and breastfeeding has been invaluable to understanding DOHaD and improving maternal and child health.  

Patient Advisory Groups in Diabetes Research- iCARE

Q and A with iCARE co-chair Jackie McKee 

 Jackie McKee, an advisor and co-chair for the iCARE cohort study, was recently featured on Knowledge Nudge (a site devoted to Knowledge Translation, and Patient Engagement). To learn more about her experience within diabetes research, please read the full blog here

PATIENT ADVISORY GROUPS IN DIABETES RESEARCH- iCARE  

Q & A Blog Post with Shayna Quoquat

Shayna Quoquat, a youth advisor for the iCARE cohort study, was recently featured on Knowledge Nudge (a site devoted to Knowledge Translation, and Patient Engagement). To learn more about her experience as a youth advisor within diabetes research, please read the full blog here. To read a Q and A with Dr. Brandy Wicklow about the iCARE patient advisory group, read here

Publications

JAMA Pediatrics 

New research published in JAMA Pediatrics by Dr. Brandy Wicklow, Dr. Sellers and Dr. Atul Sharma examines the association of Gestational Diabetes and Type 2 Diabetes Exposure In Utero With the Development of Type 2 Diabetes in First Nations and Non–First Nations Offspring.

 

The result? First Nations status and type 2 diabetes exposure were associated with the highest rates of type 2 diabetes in offspring. Rates of type 2 diabetes were significantly different for gestational diabetes and type 2 diabetes exposures.

Because the risks are different for offspring, authors suggest the benefits of earlier screening in pregnancy and differential follow-up of the offspring. This article can be accessed here

Publications

JAMA Pediatrics

New research published in JAMA Pediatrics from Dr. Meghan Azad found a 63 per cent increased risk of becoming overweight among infants who were partially (versus exclusively) breastfed at three months of age, and a 102 per cent increased risk among exclusively formula-fed infants.The full article can be accessed here.

Publications

Obesity: A Research Journal

Congratulations Dr. Jon McGavock, Dr. Brandy Wicklow, Dr. Sellers, Dr. Allison Dart and other authors on their recent publication "Determinants of Readiness for Adopting Healthy Lifestyle Behaviors Among Indigenous Adolescents with Type 2 Diabetes in Manitoba, Canada: A Cross‐Sectional Study". The take home message? only 14% participants were considered ready to adopt all healthy lifestyle behaviors. The readiness to adopt all lifestyle behaviors was associated with higher positive mental health, and sense of mastery, lower perceived stress, and better glycemic control compared with youth who were not ready to adopt all lifestyle behaviours. This article can be read here

Publications

European Respiratory Society Journal

Congratulations Dr. Meghan Azad, Geert T'Jong and other authors for their new publication "Prenatal Antibiotic Exposure and Childhood Asthma: a Population-Based Study" in the European Respiratory Society Journal. The biggest take home message is that maternal antibiotic use is associated with childhood asthma, however this association is not specific to antibiotic use during pregnancy. The full article can be accessed here

Publications

Mentoring, Education and Training Corner

Check out the new work by Dr. Richard Keijzer and Dr. Eric Benchimol in their publication "Living like an Academic Athlete: How to Improve Clinical and Academic productivity as a Gastroenterologist". This article reviews some of the strategies, technologies and systems for becoming an "academic athlete" (borrowing from a phrase in Harvard Business Review on becoming a "corporate athlete"). This article can be accessed in the 'Mentoring, Education and Training Corner' here.   

Publications

Birth Issues in Perinatal Care

Congratulations to Dr. Meghan Azad, Dr. Jon Mcgavock, Dr. Alan Becker and all other authors on their recent publication "Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity" in Birth Issues in Perinatal Care. This work highlights how exclusive breastfeeding in hospital is associated with longer breastfeeding duration, particularly among women of lower socioeconomic status. The full article can be accessed here

Publications

American Journal of Pathology

Congratulations to Dr. Hesam Movassagh, Dr. Andrew Halayko and affiliated authors for their recent publication "Semaphorin 3E Alleviates Hallmarks of House Dust Mite-Induced Allergic Airway Disease" in the American Journal of Pathology. This work relates to the ongoing development of murine models of asthma that investigate interventions and help to decipher the patho-biological origins and exacerbations of allergic airway disease. 

Publications

Critical Reviews in Clinical Laboratory Sciences

Congratulations to Prasoon Agarwal, DREAM Diabetes Theme post-doctoral fellow, the lead author of a review written together with his colleagues in the DREAM theme (Taylor Morriseau, Stephanie Kereliuk, Dr. Brandy Wicklow, Dr. Christine Doucette Doucette) that was recently published in the journal Critical Reviews in Clinical Laboratory Sciences. This paper is a comprehensive review of 200 recent original research articles covering recent experimental findings that test the Developmental Origins of Health and Disease theory with evidence from both human cohort studies and animal model systems. Specifically this review critically evaluates how maternal obesity and diabetes during pregnancy influence the developmental origins of cardiometabolic disease in the offspring and how epigenetic mechanisms are implicated. The authors address limitations and areas requiring further study so that knowledge can lead to advancements in screening, prevention and therapeutic approaches for children at risk of cardiometabolic disease development.The full article can be accessed here

Publications

Dr. Nathan Nickel 

Congratulations to Dr. Nathan Nickel, Dr. Maureen Heaman and other authors for their recent publication in BMJ. Led by Dr. Nathan Nickel, the paper examines a protocol for establishing an infant feeding database linkable with population-based administrative data within Manitoba, Canada. The full publication can be accessed here. 

Publications

DEVOTION Network Strategic Plan 2017-2020

After consulting with the various stakeholders that help to support this Network, the DEVOTION Network Strategic Plan for 2017-2020 has been developed. This plan includes 3 strategic priorities that need to be addressed within the next 3 years, including: increasing scientific capacity, stakeholder engagement, and developing a sustainable operation model. This document can be accessed and read here

 

Publications

Partners in Inner-city Integrated Prenatal Care (PIIPC) Final Evaluation Report

Congratulations to Dr. Maureen Heaman and her team on publishing the Partners in Inner-city Integrated Prenatal Care (PIIPC) Final Evaluation Report. An informative infographic highlights the health-system improvements associated with PIIPC.  

More information on PIIPC can be accessed here

 

Publications

Complexities of human milk

Congratulations to Dr. Meghan Azad’s recent publications in the International Journal of Obesity regarding a new study. Led by Dr. Meghan Azad, the paper examines the potential effect of three breastmilk hormones (adiponectin, leptin and insulin) on infant body composition and explores the association of maternal characteristics with variations in these hormones. The data was collected from the CHILD Study, which was launched in 2008 by CIHR and AllerGen NCE. 

 

The abstracts can be accessed here.

Publications

Scientific Reports

Congratulations to Naghmeh Khoshgoo, Drs. Richard Keijzer and Andrew Halayko along with other authors, on their recent publication in Scientific Reports, which demonstrates for the first time that miR-200b plays a role in peripheral lung development by maintaining an epithelial cell phenotype. The full publications can be accessed here.

Publications

Dr. Jon McGavock

Congratulations to Dr. Jon McGavock’s recent publications -

 

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis. Guillemette L, Durksen A, Rabbani R, Zarychanski R, Abou-Setta AM, Duhamel TA, McGavock JM, Wicklow B. Int J Obes (Lond). 2017 Jul;41(7):999-1. The abstracts can be accessed here, and the full text can be accessed here

Examining the impact of a province-wide physical education policy on secondary students' physical activity as a natural experiment. Hobin E, Erickson T, Comte M, Zuo F, Pasha S, Murnaghan D, Manske S, Casey C, Griffith J, McGavock J. International Journal of Behavioral Nutrition and Physical Activity 2017. The full text can be accessed here

Association Between Handgrip Muscle Strength and Cardio-Metabolic Z-Score in Children 6 to 19 Years of Age: Results from the Canadian Health Measures Survey. Rioux B, Kuwornu P, Sharma A, Tremblay MS, McGavock J, Senechal M. Metabolic Syndrome and Related Disorders. 2017. The abstracts can be accessed here.

Publications

Dr. Meghan Azad

Congratulations to Dr. Meghan Azad’s recent publications - 

 

Timing of food introduction and development of food sensitization in a prospective birth cohort. Tran M, Lefebvre DL, Dai D, AZAD MB, Subbarao P, Lou W, Becker AB, Mandhane PJ, Turvey SE,  Sears MR, and the CHILD Study investigators. Pediatric Allergy and Immunology May 2017 doi: 10.1111/pai.12739 [IF 3.9]. The abstracts can be accessed here, and the full text can be accessed here.

Breastfeeding, maternal asthma and wheezing in the first year of life: a prospective longitudinal birth cohort study.AZAD MB*, Vehling L, Zihang L, Dai D, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR and the CHILD Study Investigators. European Respiratory Journal May 2017 49(5). DOI: 10.1183/13993003.02019-2016 [IF 8.3]. The abstracts can be accessed here

Fecal short-chain fatty acid variations by breastfeeding status in early infancy: differences in relative versus absolute concentrations. Bridgman SL, AZAD MB, Field CJ, Haqq AM, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Sears MR, Scott JA, Wishart DS, Kozyrskyj AL, and the CHILD Study Investigators. Frontiers in Nutrition April 2017 4:11 doi: 10.3389/fnut.2017.00011. The abstracts can be accessed here, and the full text can be accessed here

Publications

Dr. Maureen Heaman

Congratulations to Dr. Maureen Heaman’s recent publications -

Examining Early Childhood Health Outcomes of Children Born Late Preterm in Urban Manitoba. Crockett LK, Brownell MD, Heaman MI, Ruth CA, Prior HJ. (2017). Maternal and Child Health Journal. Published online 14 July 2017, doi:10.1007/s10995-017-2329-5. The abstracts can be accessed here here.

 

Partner disengagement from pregnancy and adverse maternal and infant outcomes. Urquia, M., Pulver, A., Heaman, M., Ray, J., Daoud, N., & O’Campo, P. (2017). Journal of Women's Health, 26(3), 234-240.  DOI: 10.1089/jwh.2015.5627. The abstracts can be accessed here.

Publications

Journal of Dental Research

Congratulations to Dr. Bob Schroth, a DEVOTION member, and team on their recent paper on the microbiome associated with severe caries in First Nations children, published in the Journal of Dental Research (JDR). JDR is the second highest indexed oral health journal.  The full publications can be accessed here.

Publications

Canadian Medical Association Journal

Congratulations to members of the DEVOTION network on their recent publication in Canadian Medical Association Journal entitled Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Drs. Meghan Azad, Jon McGavock and Brandy Wicklow are members of the DEVOTION network that contributed to this publication along with other authors. It examined the links between artificial sweeteners to risk of long-term weight gain, heart disease and other health issues. The publication can be accessed here.

Publications

International Journal of Molecular Sciences

Top cited papers

James (Jim) Davie

Congratulations to Stephanie Kereliuk and Gabriel Brawerman for the review in the International Journal of Molecular Sciences, which is about how maternal macronutrient consumption affects the developmental origins of metabolic disease in the offspring. The abstract can be accessed here, and the paper can be accessed here. Dr. Vern Dolinsky, who is also part of the DEVOTION network, is another author of the paper. The infographic above is a graphic representation of the topic.              

Congratulations to Jim Davie, whose 2006 paper in Molecular Biology is among the top cited papers published that year, becoming a “Classic”. Classic papers are highly-cited papers in their area of research that have stood the test of time. For each area, Google Scholar lists the ten most-cited articles that were published ten years earlier. Read Jim's paper here.
 

Brittany Moyce

Gradzette interview

Her passion in research

Brittany L. Moyce, a third year PhD student, is part of the Dolinsky Lab at the Children’s Hospital Research Institute of Manitoba. She was recently interviewed by Gradzette and she talked about her research project which focuses on the effect of adiponectin, a fat tissue-derived hormone demonstrated to improve insulin sensitivity, on gestational diabetes mellitus (GDM).  View the full article here.

Media Coverage

Professor Jon McGavock on CJOB

Professor Jon McGavock talked about his program of research including DREAM and DEVOTION on CJOB’s Mackling And Megarry on June 9. The interview can be found here (please select June 9 starting at 2pm, the interview can be heard at 2.05pm). This audio recording is available until June 19

Publications

Congratulations

Congratulations to members of the DEVOTION network on their recent publication in Molecular Metabolism entitled Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and male mice. Drs. Christine Doucette and Vern Dolinsky are members of the DEVOTION network that contributed to this publication along with six other authors.

Congratulations to Dr. Meghan Azad of her recent publication in European Respiratory Journal entitled “Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study”. The research shows that breastfed babies have a reduced rate of wheezing, putting them at a lower risk for asthma later on.  Lorena Vehling is the co-researcher, and the Sketch document can be found here.

Two studies that are very relevant to chronic lung disease and DOHaD were published recently in the American Journal of Respiratory and Critical Care Medicine. Click on the title to assess the full article.

1. Asthma Trajectories in a Population-based Birth Cohort: Impacts of Air Pollution and Greenness
2. Preeclampsia Associates with Asthma, Allergy, and Eczema in Childhood 

Recent studies: Chronic lung disease and DOHaD

Brittany Moyce

Gradzette interview

Her passion in research

Brittany L. Moyce, a third year PhD student, is part of the Dolinsky Lab at the Children’s Hospital Research Institute of Manitoba. She was recently interviewed by Gradzette and she talked about her research project which focuses on the effect of adiponectin, a fat tissue-derived hormone demonstrated to improve insulin sensitivity, on gestational diabetes mellitus (GDM).  View the full article here.

Publications

Congratulations 

Congratulations to members of the DEVOTION network on their recent publication in Paediatric Respiratory Reviews entitled Diabetes in pregnancy and lung health in offspring: developmental origins of respiratory disease.  This review article showcases the collaborative nature of DEVOTION by including researchers from all four DEVOTION pillars (clinical research, basic research, population health and policy) along with our trainees.  Use this link to access the publication and the video abstract for the manuscript.

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